Rhogam and Pregnancy Stealth Mercury Assault
By Stephen C. Marini, D.C., PhC
There have been far too many moms at my seminars the last 3 months reacting with
alarm, surprise and anger to my cautioning them regarding giving Rhogam during
pregnancy. As you can guess, these moms received the rhogam injections during
their pregnancy and are now caring for neurologically injured children. They
were never aware that these shots could be harmful to their fetus. It is
frightening to contemplate how many mothers are getting these shots while
pregnant without realizing the potential for fetal neurological damage. What's
the deal?
Rhogam is a human gamma globulin (antibodies) directed against the Rh positive
factor of blood. It is given to Rh negative mothers who give birth to Rh
positive babies. The shot is designed to prevent these moms from becoming
sensitized to the baby, rh+ blood. Once the mom becomes sensitized to this rh
factor, there is the possibility of mom's immune system destroying the red blood
cells of her next child. Historically, babies born after mom's immune system
destroyed their blood cells acquire hemolytic disease of the newborn (HDN). 1
These babies require exchange transfusions after they are born. Such
transfusions can now be done in utero.
To prevent rh- moms from becoming sensitized to baby rh+ blood. Rhogam is
usually given within 72 hours after the birth of the rh+ baby. 2 There is a
likelihood of baby blood, only 15 ml is needed, mixing with mom's blood during
the birth process when the placental membrane breakdown. During pregnancy there
is no mixing of mother's blood with baby blood. Giving mom
rhogam after the baby's birth is sufficient to reduce the risk of HDN in her
next child to about 1-2%. Rhogam is also indicated if the mom has an abortion,
either natural or induced, or has abdominal trauma or an amniocentesis. Giving
rhogam during pregnancy can reduce the risk of HDN by less than 1%. 2 It is
doubtful that the slight benefit acquired by giving rhogam during pregnancy
outweighs the risks to the fetus from the injection.
So what is the problem with giving the rhogam during pregnancy? The standard
rhogam preparations contain the mercury compound, thimerosal. We commonly link
this preservative with vaccines. Rhogam is a type of vaccine but not a vaccine
directed against an infectious disease. The PDR cautions that the use of rhogam
during pregnancy can have adverse effects on the fetus, 2. The high mercury
content of the rhogam preparation can have serious neurological consequences on
the developing fetus. Hair analysis of unvaccinated children born from mom's
injected with rhogam demonstrate the presence of mercury. It is essential that
these babies seek appropriate medical care to chelate and remove this mercury as
soon as possible. How many babies have suffered permanent damage due to mercury
toxicity from this desire to reduce the risk of HDN by less than 1% by injecting
pregnant mothers?
How do we avoid damaging these children? First, mom's should question the
rationale for injecting them while pregnant. Second, if rhogam administration
during pregnancy is absolutely necessary then mom's should demand mercury free
rhogam. Many moms report to me that their physicians blow them off when
confronted with the request for mercury free rhogam or say that such a product
is not yet available. The reality is that mercury-free rhogam is available in
this country from Bayer Pharmaceuticals under their product name of BayRoh-D.
This mercury free product has been available sine 1996. Their number is
800-468-0894.
References available at:
www.icpa4kids.com/chiropractic_newsletter_references.htm
http://www.icpa4kids.org/research/articles/pregnancy/rhogam_newsletter.htm
the ICPA.
I don't have compiled information on Rhogam......I do know
that they started using Rhogam during pregnancy in the late 1980s. Before that,
it was give IMMEDIATELY after birth. Many women get multiple Rhogam shots now
DURING pregnancy, without a second thought from their OB. Until about 2001, each
Rhogam shot had 25mgm of mercury in it.....horrid for the rapidly growing
nervous system of the fetus!! Stephanie Cave, MD told me that she did a survey
of patients in her office....62% of autistic kids had Rh- moms....only 3% had Rh+
moms.....and she said that those kids were more difficult to treat (probably
more true neurological damage that occurred during embryological
development--that would be my "guess")
Dr Sherri
RhoGAM [licensed 1968]
On April 16, 2001, Ortho Diagnostics was approved by FDA to produce RhoGAM
without thimerosal, and at that time, Ortho agreed to distribute only
thimerosal-free product to the US market. The product has a 2-year dating
period, so that material released before April 16, 2001 may still be on the
market. The package insert for RhoGAM containing thimerosal (i.e., for those
lots manufactured prior to April 2001) does state that this product contains
thimerosal. However, there is no warning in the package insert related to
thimerosal or mercury content.
Regarding the total thimerosal content of the previously released RhoGAM, the
product was manufactured in two doses only: the standard dose of "300
micrograms" of anti-D, and the micro-dose of "50 micrograms" of anti-D. The fill
volume for both the standard dose and micro-dose products is typically between
0.6 and 0.8 mL. Preservative-containing RhoGAM contains thimerosal at 0.003%, or
30 micrograms per milliliter. Thimerosal is about 50% ethyl mercury by weight.
Hence, a patient receiving a dose of RhoGAM (0.7 ml on average) will have
received 10.5 microgram of ethyl mercury.
There are three indications for which an Rh-negative pregnant woman would
receive a significantly larger dose of RhoGAM: a fetal-maternal hemorrhage early
in the pregnancy, a fetal-maternal hemorrhage greater than 15 ml of Rh+ red
cells, and an Rh+ transfusion. In the first case, a single 300 microgram dose of
RhoGAM, is recommended at 12-week intervals. For the second two indications, a
procedure exists by which to determine the dose of RhoGAM required, based on the
amount of Rho+ red cells in the maternal circulation: the Kleihauer-Betke
elution test (see the AABB Technical Manual, 13th ed., pp. 507-8.) The total
dose of mercury received can be calculated by multiplying the number of RhoGAM
syringes administered by 10.5 micrograms.
BayRho [licensed 1971]
The Bayer Corporation makes a Rho (D) Immune Globulin product (BayRho) which in
the past contained thimerosal; this product has been manufactured without
preservative since 1996, so that no in-date BayRho contains thimerosal.
Regarding the previously distributed product, the volume of a single dose of the
Bayer product was approximately 0.7 ml. The thimerosal concentration was 0.01%,
so the total mercury in a single dose would have been approximately 35
micrograms of ethyl mercury.
WinRho SD [licensed 1996]
The Cangene Corporation makes a freeze-dried Rho (D) Immune Globulin (WinRho
SD); this product has never contained a preservative.
In addition, five other plasma-derived products remain on the market that
contain or contained ethyl mercury preservatives. They are as follows:
Antivenin (Crotalidae) Polyvalent (Equine); Pit viper snake antivenom, Wyeth
Antivenin (Micrurus fulvius); Coral snake antivenom (Equine), Wyeth Crotalidae
Polyvalent Immune Fab (Ovine); Pit viper snake antivenom, Protherics Antivenin (Lacrodectus
mactans); Black Widow spider antivenom Equine), Merck Lymphocyte Immune
Globulin: Anti-thymocyte Globulin (Equine), Pharmacia and
Upjohn
Pit Viper [Antivenin (Crotalidae) Polyvalent, licensed 1954] and Coral Snake
[Antivenin (Micrurus fulvius), licensed 1967] antivenoms by Wyeth
These products are equine antisera. They are in lyophilized form and when
reconstituted contain 0.005% thimerosal (50 micrograms per milliliter). The
diluent, WFI, contains the preservative phenylmercuric nitrate at 0.001%
concentration (10 micrograms per milliliter). A patient bitten by a snake may
receive 15 or more vials (doses of 50 vials have been reported) if the
envenomization is
severe. A 15 vial dose of this antivenom would contain 4.7 milligrams of
mercury.
Wyeth plans to discontinue these products; however, the current supply will last
1-2 years. Rattlesnake bites are dangerous and can cause serious morbidity or
mortality. In the interest of the public health these products need to be
available until sufficient Ethyl mercury-free product can be provided to the
public.
Pit Viper antivenom [Crotalidae Polyvalent Immune Fab (Ovine) licensed October
2000, Protherics]
Mercury is not added to the final product in the form of a preservative, but
thimerosal is used to assure that the affinity columns used in the manufacturing
of this product do not become bacterially contaminated with repeated use. The
product was approved but the Ethyl mercury content was limited to not more than
104.5 micrograms Ethyl mercury per vial, with a recommended maximum dose of 18
vials. A patient receiving this product would receive about 1.88 milligrams of
mercury.
Black Widow Spider antivenom [Antivenin (Lactrodectus mactans), licensed 1936,
Merck]
This product is an equine antiserum. The reconstituted product contains 0.1
milligrams of mercury per milliliter, so that the maximum 2-vial dose would
contain 0.25 milligrams of mercury. Black Widow Spider bites can be lethal, and
the dose is limited to not more than two vials. It has been determined that
removal of the product from the market by the FDA would not be in the best
interests of public health. Anti-thymocyte Globulin [Lymphocute Immune Globulin,
licensed 1981, Pharmacia & Upjohn]
This product is an equine immune globulin. In 1995 a thimerosal-free formulation
was approved and in 1998 thimerosal was removed from manufacturing.
More on Rhogam:
Most physicians will tell you that you can never change your Rh- status.
But there are some women who have done it by changing their diets and
taking certain herbs. The women in question were known to be Rh- and when
they went to the doctor for a routine test, it was found that they were
suddenly Rh+. The doctor is the one that discovered this. It is not known
how long it took for this change to occur, but the women were following
blood cleansing procedures such as:
1. Changing their diet and eliminating all sugar, white flour, caffeine,
sodas,
processed foods, and alcohol.
2. Using a lower bowel tonic and occasional colonics to keep the bowel
clear.
3. Use of herbs to cleanse the blood such as:
A. Periwinkle
B. Red Raspberry Leaf Tea
C. A tea made from red clover blossoms, chaparral, licorice root,poke
root,
peach bark, Oregon grape root, stillingia, cascara
sagrada,sarsparilla, prickly ash bark, burdock root, and buckthorn bark.
D. A few capsules of: goldenseal root, blessed thistle, cayenne,
cramp bark, false unicorn root, ginger, red raspberry leaves, squaw vine and
uva ursi.
And a few capsules of: black cohosh, sarsparilla, ginseng,
licorice, false unicorn, holy thistle and squaw vine.
4. Also, included in the diet blood builders, such as grape juice, molasses,
beets, and others.
I am simply sharing all this with you because I believe it is dangerous to
take the Rhogam shot. If you are tested and are told you need the shot,
please do not rush into this decision. I believe that you have other options
besides permanently damaging your immune system. They used to administer the
shot within 72 hours after birth. Now, they want to administer it to all
pregnant women who are Rh- without even testing them to see if they need it.
I would not accept the shot without testing to see if I needed it. And if
they said I did need it, I would do everything in my power to avoid it. Of
course, if you refuse the shot, your doctor may refuse to attend your birth.
But there are other options for birth besides physician attended birth.
Also, the hospital emergency room and the doctor on call on the labor and
delivery floor are required to give you care if you show up.
What is the bottom line in all this? As we take a step further in
technological advancement, we are getting farther and farther away from trust
in our bodies, farther from the knowledge of how to have safe and healthy
birth, and closer to permanently endangering our health and the health of our
children. We do not know the effect these substances will have on the
reproductive health of the children we carry while taking these drugs. But
we do know that it is possible to have a health pregnancy and birth without
taking the Rhogam shot. I am personally acquainted with women who have not
taken the shot, and have suffered no ill effects.
Exercise your right of informed choice. Do your own research, and don't be
pushed one way or the other. Consult your inner wisdom and only do what
feels right to you.
Read more at: http://www.whale.to/a/rhogam.html
When you do your own study on your own product and come to
the conclusion its safe is that ethical?
Lack of association between Rh status, Rh immune globulin in
pregnancy and autism
http://www3.interscience.wiley.com/cgi-bin/abstract/114264055/
Judith H. Miles *, T. Nicole Takahashi
Thompson Center for Autism and Neurodevelopmental Disorders, and Department of
Child Health, University of Missouri Hospitals and
Clinics, Columbia, Missouri email: Judith H. Miles (milesjh@missouri.edu)
*Correspondence to Judith H. Miles, Department of Child Health, Thompson Center
for Autism and Neurodevelopmental Disorders, University of Missouri Hospitals
and Clinics, #1 Hospital Drive, Columbia, MO 65212. How to cite this article:
Miles JH, Takahashi TN. 2007. Lack of association between Rh status, Rh immune
globulin in pregnancy and autism. Am J Med Genet Part A.
Funded by:
Johnson and Johnson Company
Leda J. Sears Trust
Keywords
autism • Rh • Rh immune globulin • thimerosal • RhoGam
Abstract
Though causes of autism are considered largely genetic, considerable concern
remains that exposure to Rh immune globulin (RhIg), which until 2001 in the
United States contained the preservative thimerosal, can cause autism. To
determine whether mothers of children with autism are more likely to be Rh
negative (Rh-) or to have received RhIg preserved with thimerosal, which is
49.6% ethyl mercury, we surveyed families of children with an autism spectrum
disorder (ASD) ascertained through a University-based autism clinic considered
free of ascertainment biases related to type of autism or severity. Between
2004 and 2006, 305 mothers of 321 children with an ASD agreed to participate in
a telephone interview. Analysis of complete records including the blood group
status and RhIg exposure of 214 families showed that Rh- status is no higher in
mothers of children with autism than in the general population, exposure to
antepartum RhIg, preserved with thimerosal is no higher for children with autism
and pregnancies are no more likely to be Rh incompatible. This was also true for
autism subgroups defined by behavioral phenotype, gender, IQ, regressive onset,
head circumference, dysmorphology, birth status, essential, or complex
phenotype. These findings support the consensus that exposure to ethylmercury in
thimerosal is not the cause of the increased prevalence of autism. These data
are important not only for parents in this country but also for the
international health community where thimerosal continues to be used to preserve
multi-dose vials which in turn makes vaccines affordable. © 2007 Wiley-Liss,
Inc.
From SafeMinds, thanks to Elizabeth Kilpatrick.
http://www.safeminds.org
University of Missouri Study on Link Between Autism and Mercury a Discredit to
Sound Science Undisclosed industry funding, unsubstantiated conclusions on
vaccines, and study sample alteration undermine credibility on controversial
topic.
A recent press release from the University of Missouri announced the results of
a study on autism and Rh immune globulin (RhIg) injections, some of which
contained a mercury preservative called thimerosal. SafeMinds reviewed
information about this study and found several troublesome aspects, including
undisclosed industry funding, unsubstantiated conclusions on vaccines and
mercury, and deviation from acceptable scientific practice.
The study was funded by Johnson & Johnson, the largest manufacturer of RhIg
products and the defendant in several lawsuits alleging a link between autism
and mercury in RhIg. In an earlier 2005 poster presentation, the study authors
acknowledged that the research was "supported by Johnson & Johnson
Pharmaceutical Research," but the University of Missouri press release omits
mention of this conflict of interest.
The press release headline falsely claims that the "Study Finds No Link Between
Autism and Thimerosal in Vaccines." The study is about Rh immune globulin, and
immune globulins are not vaccines. "The headline deceives the public," noted
Mark Blaxill, director of SafeMinds. "It says an autism-mercury in vaccines link
has been disproved when the research did not do so." In fact, the study failed
to differentiate between mothers who received RhIg brands with mercury and those
receiving the brand without mercury, rendering assessment of mercury's role in
autism from RhIg indeterminate.
Changes to the research sample were made in the middle of the study. The 2005
sample contained 47 mothers with more than one child with autism, while the
final 2007 study only had 16 mothers with more than one child with autism. The
elimination of 31 'multiplex' families means that the original sample was
altered, and not just added to, after initial results were obtained in
contradiction of standard research practice meant to prevent manipulation of
findings.
"An earlier analysis by SafeMinds of the poster presentation revealed numerous
flaws in methods, analysis and interpretation," stated Mr. Blaxill. "We are
concerned many of these flaws have not been corrected and quite possibly have
been amplified in the published paper. While the poster results demonstrated an
increased risk of autism in thimerosal-exposed children, the written
interpretation of the data claimed the opposite."
Once SafeMinds has the opportunity to review the full paper, a full assessment
will be completed. SafeMinds calls for unbiased studies on the potential link
between autism and mercury exposures. More information on this study is
available at www.safeminds.org.
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