BMJ 2002;325:569 ( 14 September )
Observational study of vaccine efficacy 14 years after trial of hepatitis B
vaccination in Gambian children
Hilton Whittle, deputy director, a Shabbar Jaffar, senior lecturer, b
Michael Wansbrough, MSc student, b Maimuna Mendy, senior scientific officer,
a Uga Dumpis, visiting research fellow, Riga University, a Andrew Collinson,
clinical scientist, a Andrew Hall, professor. b
a Medical Research Council Laboratories, PO Box 273, Banjul, Gambia, b
London School of Hygiene and Tropical Medicine, London WC1E 7HT
Correspondence to: H Whittle email@example.com
Objective: To determine the duration of protection from hepatitis B vaccine
given in infancy and early childhood.
Design: Cross sectional serological study of hepatitis B virus infection in
children of various ages 14 years after the start of a trial of vaccination
Setting: Two villages in the Gambia.
Participants: Children and adolescents given hepatitis B vaccine in infancy
or early childhood: 232 were aged 1-5 years, 225 aged 5-9 years, 220 aged
10-14 years, and 175 aged 15-19 years. Main outcome measures: Vaccine
efficacy against infection and against chronic infection in the different
Results: Vaccine efficacy against chronic carriage of hepatitis B virus was
94% (95% confidence interval 89% to 97%), which did not vary significantly
between the age groups. Efficacy against infection was 80% (76% to 84%).
This was significantly lower in the oldest age group (65%, 56 to 73). Of the
uninfected participants in this age group, 36% had no detectable hepatitis B
virus surface antibody. Time since vaccination and a low peak antibody
response were the most powerful risk factors for breakthrough infection
(P<0.001 in each case). Low peak antibody response was also a risk factor
for chronic carriage (odds ratio 95, 19 to 466).
Conclusions: Children vaccinated in infancy are at increased risk of
hepatitis B virus infection in the late teens. The risk of chronic carriage
after sexual exposure needs further assessment to determine if booster
vaccines are necessary.
(My conclusion: Hep B doesn't work)
Hepatitis B Vaccine Linked to Increase in Diabetes
A study presented to the annual meeting of the American Diabetes Association
finds that children who are vaccinated with the hepatitis B vaccine are at a
greater risk for developing type 1 diabetes than children who have never
received the vaccine.
Type 1 diabetes is where the body doesn't make enough of the insulin that it
needs and is a relatively rare condition. In the study, 150,000 children who
received the hepatitis B vaccine at 3 months of age were compared to 150,000
children who had not received the vaccine. Type 1 diabetes developed at the
rate of 46 per 100,000 in the vaccinated kids and only 34 per 100,000 in the
kids who didn't get vaccinated. Waiting to vaccinate until later in life
also seems to increase rates. In kids who didn't receive the vaccine until
they were 12 years old, the rate of type 1 diabetes was 17.8 cases per
100,000 while kids who had never received the vaccine only developed 6.9
cases per 100,000.
This is not the first time problems have been documented with the hepatitis
B vaccine. Data released at the 62nd annual meeting of the American College
of Rheumatology in November, 1998, shows that the hepatitis B vaccine has
also been linked to an increase in autoimmune diseases such as lupus and
rheumatoid arthritis in children and adults who have been vaccinated.
The Annals of Pharmacotherapy: Vol. 36, No.
12, pp. 1970–1971.
Chronic adverse reactions
associated with hepatitis B vaccination
David A Geier
President, MedCon, Silver Spring, Maryland
Mark R Geier MD PhD
President, The Genetic Centers of America, 14 Redgate Ct.,
Silver Spring, Maryland 20905-5726, FAX 301/989-1543, E-mail:
TO THE EDITOR:
Return to Top
adult hepatitis B vaccine (HBV) serious reactions, showing statistical
increases in arthritic, neurologic, immunologic, and gastrointestinal
reactions. However, some reactions analyzed may have been acute
self-limited reactions that did not lead to chronic problems. In order to
study this problem, the purpose of this analysis was to examine chronic
adverse reactions reported to the Vaccine Adverse Events Reporting System
(VAERS) database following adult HBV from 1997 through 2000. We
hypothesized that chronic conditions occurred similarly following adult
HBV and adult vaccine control group. The scientific literature contains
few studies briefly examining chronic reactions following adult HBV.2,
The VAERS is an epidemiologic database maintained by
the Centers for Disease Control and Prevention (CDC) since 1990. All
vaccine reactions are to be reported to this database as mandated by US
law. The CDC requires written and telephonic confirmation of serious
reactions and follows up serious reactions 1 year after they occur to
determine whether the patient recovered. The VAERS Working Group of the
CDC analyzes and publishes epidemiologic studies based on examination of
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We retrospectively examined adult HBV reactions
reported to VAERS from 1997 through 2000 using Microsoft Access (Redmond,
WA). We examined neuropathy, neuritis, myelitis, vasculitis,
thrombocytopenia, gastrointestinal disease, multiple sclerosis, and
arthritis reactions, where patients, based on a 1-year follow-up, were
considered not to have recovered from their reaction. These terms for
reactions were based on descriptions by those reporting them. We have
examined each of these reactions in previous studies, enabling us to
extend and expand our previous findings.
rates were based on the estimates of the Biological Surveillance Summaries
that we obtained from the CDC for the number of doses administered during
the study periods examined. The CDC estimates that 20 516 508 adult HBVs
were administered from 1997 through 2000. Additionally, as a control,
tetanus–diphtheria (Td) vaccine chronic reactions reported to VAERS from
1991 through 2000 in adults were analyzed. The CDC estimates that 141 832
679 adult Td vaccinations were administered from 1991 through 2000. The
incidence rates of adult adverse reactions in the Td vaccine recipients
provided a background rate to compare against the incidence rates of
adverse reactions in adult HBV recipients. We chose our temporal period
following adult Td vaccine so as to allow our search of the VAERS to yield
as many reactions following our adult Td vaccine control group as
possible; this would allow for an increased power in our statistical
analyses. Relative risk was determined by dividing the incidence rate of
the reaction following adult HBV by the incidence rate of the reaction
following adult Td vaccine control group. Attributable risk was determined
by subtracting 1 from the relative risk. Percent association was
calculated by dividing the relative risk by the relative risk plus 1 and
multiplying this computed value by 100. In our statistical analysis, a
2 × 2 contingency table was employed. We used the statistical package
contained in Corel's Quattro Pro and accepted a p value of 0.05 as
Return to Top
Table 1 summarizes chronic reactions reported following adult HBV in
comparison with those reported following adult Td vaccination. The results
show even more significant increases in chronic conditions following adult
HBV than acute conditions in comparison with adult Td vaccination.
In conclusion, our study demonstrates that
adult HBV is statistically associated not only with acute neuropathy,
neuritis, myelitis, vasculitis, thrombocytopenia, gastrointestinal
disease, multiple sclerosis, and arthritis, but some of these patients go
on to develop chronic adverse reactions that persist for at least 1 year
following HBV. These types of chronic adverse reactions
following adult HBV should be discussed with patients contemplating being
immunized with HBV and should be included in the differential diagnosis of
those who develop them following adult HBV.
Return to Top
1. Geier MR, Geier DA.
Hepatitis B vaccination safety. Ann Pharmacother 2002;36:370–4. [ABSTRACT]
2. Pope JE, Stevens A, Howson W,
Bell DA. The development of rheumatoid arthritis after recombinant
hepatitis B vaccination. J Rheumatol 1998;25:1687–93. [PubMed
3. Grotto I, Mandel Y, Ephros M,
Ashkenazi I, Shemer J. Major adverse reactions to yeast-derived hepatitis
B vaccines — a review. Vaccine 1998;16:329–34. [PubMed
4. Singleton JA, Lloyd JC, Mootrey GT,
Salive ME, Chen RT, the VAERS Working Group. An overview of the Vaccine
Adverse Events Reporting System (VAERS) as a surveillance system. Vaccine
R Geier and David A Geier have done consulting work before the no-fault
Vaccine Compensation Act administered by the US Court of Claims, involving
adverse reactions to hepatitis B vaccine. David A Geier is president of
MedCon, a medical–legal consulting firm that assists vaccine injury
patients in obtaining funds from both the National Vaccine Injury
Compensation Program and through civil litigation.
health archive how to read a news script index of
previous eye on health scripts
hepatitis b new information!!! more information
[air date=6pm monday 4-27-98][repeat=11pm monday 4-27-98]
every day, in clinics nationwide, children get vaccinated to protect them
from disease. we, as parents, trust those immunizations will save lives--
and not hurt people. but, eye on health reporter kristi krueger has found
one vaccine is causing concern among some doctors, and it's a vaccine that's
mandatory for *your* children. this report isn't meant to scare you! but, i
think it's important for you to know the very real concerns a growing number
of doctors *worldwide* have about the hepatitis b vaccine.
a series of three shots are supposed to protect people form a horrible virus
that attacks the liver. the problem is, some experts fear it may be the
*vaccine* is doing the attacking. on french national television....at a lab
in houston...exam rooms around the world...and a home in south florida....concern
about the hepatitis b vaccine is growing. doctors say the vaccine may have
debilitating side-effects for some people. many states, including florida,
mandate children get it. [super: dr. andrew campbell/houston immunologist]
"we now are seeing a whole bunch of people very affected whose lives have
been destroyed by this product."
in this adverse reaction document compiled by the federal government,
thousands of people reported developing everything from fevers and flu to
arthritis, blindness, chronic fatigue syndrome and multiple sclerosis soon
after having the vaccination.
it's the not the first vaccine linked to adverse reactions. a whooping cough
vaccine and the swine flu vaccines were both banned. [campbell] "i think
this is extremely dangerous. i think this is an issue that requires the
federal government to step in immediately." one coral springs family hopes
that happens. 15 year old lindsay kirschner might not look ill, but she is.
lindsay's,problems started four days after her first hepatitis b shot last
[super: marilyn kirschner/mother] "she's constantly dizzy, nauseous,
vomiting. she is having problems with her sight, running from blurriness to
total black-outs." it wasn't until lindsay's third shot that her doctors and
parents made a connection. [super: lindsay kirschner/patient] "i used to
love to roller blade and play tennis and now that's really hard for me." [marilyn]
"it's a never ending battle. i don't think there's a day since she's been
sick that i haven't spoken with a doctor." one houston doctor she spoke to
was vaccine researcher bonnie dunbar. for most of her career, dr. dunbar has
developed vaccines. she's written books, and won national awards. for the
last two years she's studied potential side effects of the hepatitis b
[super: bonnie dunbar, ph.d./baylor college of medicine]"there are several
different types of side effects. but they are all associated with what we
call auto-immune disorders. that is the body's immune system has turned
against itself." two years ago, both dunbar's brother and a lab assistant
got sick soon after getting the hepatitis b vaccine. dr. dunbar learned
they're not alone. [dunbar] "there's one report from a nurse who reported 15
cases of ms following the vaccine." here's how dr. dunbar explains it. some
people are predisposed to autoimmune disorders. in these people, she thinks
the genetically-engineered vaccine may be doing a changing act called
molecular mimicry-- *causing* the symptoms it was meant to prevent.
[dunbar]"but what is amazing to me is the number of doctors, nurses, health
care workers and people who were totally active and healthy." [super:
krueger/eye on health]"from her lab here at the Baylor college of medicine,
dr. Dunbar is putting her career on the line asking the federal government
to stop, take a step back, and really study the long term effects of the
hepatitis b vaccine." [Dunbar]" doctors need to be warned to look out for
these side effects."
dr. Andrew Campbell is looking out. he's treating dozens people who he
believes developed a severe rash and auto-immune problems after getting the
vaccine. dr. Campbell fears there are many sick people who don't know the
hepatitis b vaccine may be to blame. [Campbell] "we are going to see some
major health concerns throughout the country that is going to decimate the
public." right now, french doctors and patients are pressuring their
government for long term studies.... doctors in canada and england are doing
the same. the vaccine makers, and our government maintain there have been
isolated reactions... but millions are vaccinated without incident.
[dr. Walter Orenstein/centers for disease control] "no vaccine is completely
safe or completely effective.. and what we try to do is balance the benefits
with the risk." but back in coral springs... the kirschers just want lindsay
to get better. [marilyn] "i can't even think about the future because
thinking about tomorrow is hard enough.. and thinking about how we're going
to get through each day." we spoke to the two drug companies that make this
vaccine. we were told if more cases of adverse reactions are reported,
that's what happened with both the old whooping cough and swine flu
vaccines. once people spoke out about side effects, both vaccines were
pulled off the market. one more note. the hepatitis-b vaccine was mainly
studied in asia and africa. but dr. dunbar says most of the problems she's
seen are in caucasions. that leads her to believe there's something
*genetic* going on here. what should parents do? don't stop getting
vaccines! they are lifesavers! but, inform yourself. talk to your doctor. he
or she has a physicians desk reference. this book clearly outlines all
possible drug reactions. finally, no one is asking for a ban on this
vaccine. it helps many people. but, doctors want long-term research to
discover why certain people are having adverse reactions. to report an
adverse reaction to a vaccine, or if you want more information, call the
national vaccine information center at (800) 909-shot. their website url is
hepatitis b follow up we have more information about the hepatitis b
vaccine...and whether it could be harming... not helping your children. ever
since our story on the possible side effects of the hepatitis b vaccine
first aired last night... our phones have been ringing off the hook.
doctors' offices have been busy too... fielding calls.. and answering
questions about the vaccine. eye on health reporter kristi krueger broke the
story. she's here with more on hepatitis b. [kristi] parents, doctors, and
public health experts are reacting tonight to new concerns about the
hepatitis b vaccine-- a vaccine all florida children are required to get.
we're hearing from doctors-- who tell us there is no reason for people to
avoid the vaccine. statistics show it's protected thousands of people from a
deadly disease. we've also heard from more people-- who say the vaccine made
them very sick.
[super: kendall/eye on health]
the past few months have been tough for phyllis noe (no-ee). she got her
hepatitis b shots late last year. noe is convinced the vaccine gave her
seizures. [super: phyllis noe/patient] "i felt faint, dizzy, so some of the
people i work with had me lie down, and then i started having seizure like
noe wanted to talk to us-- after hearing about lindsay kirschner's reaction
to the hepatitis b vaccine. the fifteen-year-old coral springs girl has been
diagnosed with chronic fatigue syndrome and heart problems. she got very
sick after being vaccinated. [super: marilyn kirschner/mom] "the next day
she woke up and couldn't stand up without holding the walls of the house.'
houston vaccine researcher doctor bonnie dunbar-- has been studying
potential problems for 2-years. today, she's gotten dozens of calls from
people convinced hepatitis b vaccinations made them sick. dunbar wants the
federal government to take a closer look mat these vaccines-- so far-- she
says no one has listened.
[(dunbar]"i was told by one major agency, for which i consulted, that my
research and ideas about this belong in church, not in a laboratory." in
dunbar's lab-- she's been looking at potential reactions--such as fevers and
flu--to arthritis, blindness, and multiple sclerosis-- in people who've had
pediatricians' offices-- like this one in coral gables-- and the miami
children's hospital-- were flooded with calls today from scared parents who
know the vaccine is required for school children. parents are being
assured, the number of people protected by the vaccine-- far outnumber the
people who've experienced serious side effects.
[dr. elani sfakianaki/florida dept. of health] "now side effects occur in
one in every 10-thousand vacciantions. that's a very rare occurence." and
the health department wants anyone who's had medical problems following
*any* vaccination to call: national vaccine injury compensation program
if you would like some more information.. we've set-up a hotline number at
the station... the number is 305-325-2435.
[air date= 6pm wednesday 4-29-98 ]
more people who got the hepatitis-b vaccine and then got sick are speaking
out tonight, saying it's the vaccine's fault they're sick. kristi krueger
broke the story to the country this week. she has more tonight from
patients, doctors and public health experts. kristi. the hepatitis-b
vaccine is required for enrollment into kindergarten in florida this fall.
and, that's cause a lot of concern among parents. but, the state department
of health *insists* the vaccine is *extremely* beneficial and school kids
*need* the vaccine. but, some people who say they got sick nafter getting
the shots question the safety of the vaccine.
[super: cooper city]
Anthony sikora's motor skills haven't been the same since he got vaccinated
against hepatitis-b when he was four. his coordination was so bad, the staff
at Anthony's day care center got worried. [super: gale sikora/Anthony's mom]
"then his day care teacher called me and said i don't know what's wrong, but
when kids bump into him on the playground, he just falls over." now
is seven. after test after test, he's now diagnosed with ataxia. the boy's
neurologist and pediatrician both say Anthony's condition was the result of
his hepatitis-b vaccination.
[super: kristi krueger] "Anthony's doctors did report his adverse reactions
to the fda. but some experts are very concerned that other doctors are not
doing that reporting because they just don't know the symptoms."
[super: bonnie dunbar, ph.d./baylor college of medicine] "there are several
different types of side effects. but they are all associated with what we
call auto-immune disorders. that is the body's immune system turnign against
reactions such as flu and fever,arthritis,blindness, and multiple sclerosis
have been reported to the government. these symptoms are familiar to tony
lamberti of coral springs. the 24-year-old firefighter says his health has
declined since his hepatitis-b vaccinations. just days after his final shot,
he couldn't stand-up. [super: tony lamberti/firefighter] "i had hip pain,
and it just got worse as the day went on to where at the end of the day i
just couldn't walk on it. i felt like knives were being stabbed in my leg."
now tony's taking pain medicine.
[super: kathy lamberti/tony's mother] "the other night at dinner, we were
eating dinner, and my son couldn't cut his own meat. he couldn't walk by
himself." despite new concerns, the florida department of health says the
vaccinations have led to a dramatic decline in the number of hepatitis-b
infections. the department *is* concerned about adverse reaction reports.
but the state wants more proof the cases are *directly linked* to the
[sikora] "well, it's isolated, until it's your child. then it becomes a
major concern." and the department says the vaccine has helped far more
people than it has harmed. [super: dr. deise granado/miami children's
hospital] "parents have no reason to be alarmed. but they have to be on the
lookout for some mild side effects that might derive from this vaccine. and
that it is far more important for their children to be protected from the
if you've ever had an adverse reaction to a vaccine your doctor must call
the f-d-a and report it. doctors should call 800-fda-1088
and then, you need to call the national vaccine injury compensation program.
the number is 1-800-338-2382. those hurt by vaccines may be eligible for
damages. and if you would like some more information about hepatitis b..
we've set-up a hotline number at the station... the number is 305-325-2435.
people who have gotten sick from the vaccine can call the national adverse
reaction hotline at the fda. the number is 800-822-7967. also, report your
case to the national vaccine injury compensation program. tell the operator
you've been hurt by the hepatitis b vaccine. you may be eligible for
payment. call 800-338-2382. your doctor must also make a report to the
fda's medwatch. give your doctor this number. 800-fda-1088.
to reach dr. pancheta wilson, who is investigating adverse reactions, and
treating patients in coral springs-- call 954-344-2793. attorney david
krathen is helping patients with lawsuits. call 954-467-6400.
hepatitis b investigation [writer=stachowiak / krueger] [air date=6pm
tuesday 5-19-98][repeat=11pm tuesday 5-19-98] the hepatitis 'b' vaccine is
supposed to protect people from a serious-- and often fatal-- liver
infection. and the series of three shots is required among florida children.
but as eyewitness news first reported-- thousands of people suspect they got
chronically ill-- after getting vaccinated. and now, some researchers now
question if the vaccine is safe for everyone. eye on health reporter kristi
krueger broke the story a few weeks ago. she's here tonight to tell us--
what action is being taken-- to investigate this vaccine.
ever since the story broke-- we've received hundreds of calls from concerned
doctors and viewers. we've learned the federal government has heard 250 new
complaints about illnesses linked to the vaccine. and, we've heard about
dozens of south florida people who say the vaccine made them very sick.
tony lamberti is sick-- in bed-- and, he hasn't felt well since he got
vaccinated against hepatitis 'b' several months ago.
the coral springs firefighter was immunized while he was being trained as a
paramedic. now, he's in constant pain. [tony lamberti/patient]"in my
wrists, my fingers, sometimes i feel like they're broken, my knees, i get
fluid in my knees sometimes, my ankles, the bottom of my feet." lamberti's
mother, kathy, spends her days managing tony's care. she's worried about the
medical bills. [kathy lamberti]"i feel that someone should pay for my son's
illness." lamberti's doctor-- pancheta wilson--is the first south florida
physician to investigate adverse reactions linked to the vaccine. [dr.
pancheta wilson/internal medicine] "this is not a coincidence. there are too
many cases right now that have been reported to take this as a coincidence."
doctor wilson is so concerned about patients like tony lamberti she wants
action from the federal government.
[wilson] "...to pull the vaccine, until further studies are completed, and
we know how to treat these patients at least." [kristi krueger]"i've talked
at length to the centers for disease control, the food and drug
administration, and the florida department of health. *all* agencies tell me
there will be an investigation into the adverse reactions, and each
complaint will be taken seriously."
but, anthony sikora's family has heard *nothing* from the government.
anthony's mother says adverse reaction reports were filed last year by the
boy's doctors-- blaming the vaccine for causing anthony's nerve and movement
disorder. [gale sikora/anthony's mother]"he comes home and tells me the kids
laughed at me and told me i walk funny or they told me i'm stupid because i
can't write, then i get really angry."
[kathy lamberti/tony's mother]"we need help. we all need help."
but, help for tony lamberti, anthony sikora, and thousands of other
patients, may come-- only if drug companies or the government fund more
research into this vaccine. researcher bonnie dunbar develops vaccines for a
living in houston. she found out about the adverse reactions to the
hepatitis 'b' vaccine-- after her own lab assistant-- and her brother-- got
mysterious illnesses after immunization.
[bonnie dunbar, ph.d./baylor college of medicine]"we need to have a large,
epidemiological study to look at the effect to the vaccine, both from the
positive, who is going to be protected, and the other side, who is going to
have an adverse reaction." but, the vaccine makers and the government must
admit there's a possibility this shot may make people sick before any more
money is spent on research. [dunbar] "while there are millions of dollars
out there to develop vaccines, there's no money for research into adverse
reactions for people who admittedly are having these problems."
doctor dunbar says-- in the meantime-- hundreds of thousands of dollars are
being spent treating the health problems of the people who say the vaccine
made them sick. an estimated 23-thousand people who've complained to the
government about adverse reactions from the hepatitis 'b' vaccine.
meanwhile, up to 25-thousand americans get severe hepatitis 'b' infections
each year... and many more people carry the virus, but have no symptoms. the
health department-- and many doctors-- insist vaccinations continue--
because the shots do more good than harm. health archive how to read a news
script index of previous eye on health scripts hepatitis b follow-up
[air date: 6pm 6-15-98]
the hepatitis b vaccine is again under scrutiny tonight, following an
exclusive eyewitness news investigation. two government agencies are now
taking a closer look at the severe adverse reactions-- the vaccine might
cause. the response from our investigation was overwhelming. we took
hundreds of calls from concerned parents, and even from doctors critical of
our report. then today the mother of a broward boy-- who's been sick ever
since he got the hepatitis 'b' shots-- filed a lawsuit - against one
the hepatitis b vaccine was made to protect people from a debilitating
virus... patients in the original studies were followed for five days. but
some researchers think people can have adverse reactions weeks or even
months after the injection. thousands of people have reported serious
auto-immune problems to the federal government.
[bonnie dunbar, ph.d./baylor college of medicine]
"there's one report from a nurse who reported 15 cases of ms following the
vaccine. [kristi] "but the federal health officials i talked to say those
numbers can be deceiving-- that just because people *report* side effects..
doesn't mean the vaccine is to blame. but i have learned the food and drug
administration and the centers for disease control.. have started studies to
look at the possible link. one study is focusing on multiple sclerosis.. the
other on a muscle disorder called myositis. gale sikora thinks there' is a
connection.. her son anthony lost muscle control right after his first
[gale sikora/anthony's mother] "his daycare teachers called me and said i
don't know what's wrong. but when kids bump into him on the playground, he
just falls over." anthony's doctors filed adverse reaction reports with the
federal government. no one ever investigated. so today, anthony's mother
filed a lawsuit against merck..one of the companies that makes the
vaccine... claiming the company knew there could be side effects and didn't
the sikora's attorney says doctors did alert the company about the side
effects... but were ignored. [david krathan/sikora's attorney] "that causes
us great concern as to whether or not merck really wanted to know what the
answers are. but we'll find that out during the discovery process." while
the legal process begins for anthony.... the treatment process begins for
tony lamberti.. tony's doctor believe the hepatitis b vaccine made him
sick..... now, every saturday, he has hours of gamma globulin therapy....
it's a treatment people with the hepatitis b *virus* often get.
[tony lamberti/coral springs firefighter]
"i couldn't move my arms or legs. i couldn't walk around the house.. and
now, i'm practically normal again."
a spokesperson for merck... the drug company involved in the lawsuit tells
me the company never comments on pending litigation. meantime, several
researchers have submitted a grant proposal to the national institutes of
health. the study is being reviewed and we'll soon learn whether money will
be allocated for a long-term study on the hepatitis b vaccine. at the very
least, these doctors hope to get pediatricians and their patients talking
and aware of potential side effects--- especially, perhaps, in families with
a family history of auto-immune diseases.
Dear Mrs. T
I received your letter last night, forward by Pennsylvania Parents for
Vaccine Awareness. I was up until 3:00 AM, reformatting it into a MicroSoft
Word document (I've only recently acquired a computer, my skills need
improvement.) I was deeply moved by your letter and am so sad for what has
happened to your family.I am nurse who was forced to receive the shots in
nursing school. I had all 3, the last being administered March 19, 1991.
Within 2 weeks (April Fools Day 1991) I learned that I my auto immune system
was mysteriously creating anti-nuclear antibodies, detectable at 2580
What followed was nothing short of conspiratorial (long story -- let me know
if you want it.) Suffice it to say at this point that I didn't make a
connection until 1994 the cause of my injury, which a neurologist at the
Hospital of the University of Pennsylvnia (where I am employed) diagnosed
as: severe sensory neuronopathy of IDEOPATHIC origin. Also:undifferentiated
connective tissue disease has been diagnosed.
I filed a report with VAERS in early 1995. The administering hospital
neglected to record manufacturer names of the 2nd and 3rd shots. NO lot
numbers for any of them -- and yet VAERS informed me that the hospital was
not remiss in not recording this data because it was not required at that
time! While they informed me that the vaccine was not covered under the
national compensation program, they did not contact me when that changed in
August 1997. Nor have they ever offered treatment.
My condition is somewhat odd-ball, because I have a rare non-demylenating
condition. My peripheral sensory nerves were attacked, while the myelin
sheath is unaffected. Finally I learned about others following the 20/20
episode in January of this year. Because I am single and didn't own a
computer, I have been living with the impact of all this in relative
isolation up until them (although my neighbors are supportive and several
have changed their personal vaccination decisions based on our day-to-day
I am happy to report that I will be submitting blood samples to Bonnie
Dunbar, PhD for the Baylor College of Medicine study: "Mechanisms of Adverse
Reactions to Hepatitis B Vaccine." I will be forwarding your letter to Dr.
Louis Bell, Infectious Disease, Children's Hospital of Philadephia (my
former employer -- I 'put a face on one of the adult statistics' for them
just last week. I had never told any of them why I believe I developed a
steppage gait, etc.) I am also sending your eloquent letter to Huntly
Collins, medical writer for the Philadelphia Inquirer who is doing a story
in a few weeks and with whom I've interviewed.
God bless you and and your family. Please feel free to contact me if I can
be of ANY help. I did provide written testimoney to Congressman Mica's
Committee for the May 18th hearing which I attended, and have
just returned from the hearings August 3rd regarding vaccine safety. Despite
arriving to the hearings 2 hours early, my father (traveling from NH) and
myself were unable to get a seat in the main room due to the number of
line-holders Merck had paid to crowd the room 4 hours prior to the
procedings! We listened to the procedings from a remote location set up 1/2
hour after testimony had gotten' under way. With uncharacteristic boldness,
I introduced myself to Congressman Burton as he was on his way out. He is a
Susan Kreider, RN
May 18, 1999
House of Representatives
Criminal Justice, Drug Policy and Human Resources
Effectiveness of Hepatitis B Vaccine
Dr. Bonnie S. Dunbar
2001 Holcombe, #2401
Houston, Texas 77030
Congressman John L. Mica
Subcommittee on Criminal Justice, Drug Policy and Human Resources
United States House of Representatives
2157 Rayburn House Office Building
Washington, DC 20515-6143
Good morning and thank you for this opportunity to discuss these
critical health care issues. My name is Bonnie Dunbar, and I am a research
scientist and medical and graduate student professor who has worked in the
areas of autoimmunity and vaccine development for over twenty five years
(the past 17 years at Baylor College of Medicine in Houston).
I have been honored by the National Institutes of Health as the first
Margaret Pittman lecturer for my pioneering work in vaccine development.
This honor was special for me because Dr. Pittman's contributions were
instrumental in early aspects of vaccine development and because I
understand the impact that some vaccines have had, and will continue to
have, on our society. My ongoing research in the area of vaccine
development continues to be a major commitment. I have worked extensively
with the US Agency for International Development and the World Health
Organization programs and have a life long commitment to carrying out
research to understand, and hopefully, to help solving problems associated
with world population as well as disease problems.
As I have been invited to speak to this distinguished subcommittee, it is
important to discuss my experience with the clearly apparent severe adverse
effects of the Hepatitis B vaccine. About five years ago, I had two
individuals working in my laboratory who were required to take the
Hepatitis B vaccine. Both of those individuals developed severe and
apparently permanent adverse reactions as a result of the vaccine. Both of
them were completely healthy and very athletic before this vaccine and have
now suffered severe, debilitating autoimmune side effects from the vaccine.
I have studied the complete medical history of my brother, Dr. Bohn
Dunbar, who developed seriously chronic joint and muscle pain, fatigue, and
multiple sclerosis-like symptoms. And now he has further been diagnosed with
POTS (an autoimmune, cardiovascular, and neurological problem) and
subsequently with chronic inflammatory, demyelinating polyneuropathy. His
problems have been attributed to the Hepatitis B vaccine by over a dozen
different specialists around the United States of unquestionable medical
expertise. He has now been rated permanently and totally impaired at
greater than 90%. His health care has already cost the state of Texas
about a half million dollars in the Texas Worker's Compensation Program to
date, and that figure will continue to rise given the seventy of his health
My other student went partially blind following her first booster
injection, a medical condition that was markedly exacerbated by her second
booster that resulted in hospitalization. Personal communications are that
her eyesight is continuing to deteriorate. Because she is in medical school
she has been, understandably in my opinion, afraid to pursue investigation
into her medical problems because of her concern that they might affect her
I am extremely sensitive to the need to evaluate the risk vs. benefits
of any vaccine. Because of my experience in this area, it became intuitively
clear to me that these two active, healthy individuals working in my
laboratory developed autoimmune syndromes within a predictable immunological
time frame following their booster injections of the Hepatitis B vaccine.
After carrying out extensive literature research on the nature of this
virus and this vaccine, it became intuitively obvious to me that there is a
significant scientific probability that the vaccine is the cause of those
adverse reactions. Both the published studies of reactions to viral
infection and the temporal relationship of vaccine administration to adverse
events suggest strongly that these adverse reactions are related to the
nature of the viral protein, the recombinant surface antigen of which is the
principal component of the vaccine.
I have been in contact with numerous physicians and research scientists
from several countries who have independently described identical severe
reactions to the vaccine in thousands of Caucasians. Their observations
have been, for the most part, denied or ignored by the public health
systems, as is evidenced
by the serious charges against healthcare officials and pharmaceutical
companies brought recently in France. The reversal of the vaccine mandate
for children in France was not based on lack of documentation. I have now
been contacted personally by hundreds or more individuals (including
parents of infants and
children) who have reported deaths, severe health problems and life long
disabilities, resulting in major medical costs following the administration
of this vaccine. It appears that the adverse events related to this vaccine
are within a gene pool that is capable of genetic definition. I
respectfully submit that rigorous scientific studies into the possibility
that the vaccine can cause severe autoimmune disorders is necessary.
The following points specifically address the issues listed in my
invitation to speak to this committee.
1.The Food & Drug Administration has set up a system for reporting
adverse reactions to the vaccine. How does this system work? What is being
done to study these adverse reactions. My first experience with this
reporting system followed my observation of the two individuals in my
laboratory who developed serious medical problems within a time frame
predictable for immunological reactions. After seeing that these reactions
were listed in the Physician's Desk Reference text as reported reactions
to this vaccine, I learned about the VAER's reporting system. When I first
called the FDA about this, I was told by an individual that "this vaccine
is a problem and it is a big one." I was initially sent some information on
reports of reactions
that were similar, if not identical, to those of these two individuals.
I attempted to initiate a dialogue with individuals at the FDA but was
simply told that I could obtain the information under the Freedom of
Information Act. I subsequently paid to obtain copies of these documents;
and I was overwhelmed by the thousand of pages of documents I received
listing thousands of reports, hundreds of which were identical to the
reports I had filed for the two individuals working in my laboratory.
Unfortunately, the details on these lists were insufficient for studies to
critically evaluate the mechanisms by which these reactions occur.
There was no response to my subsequent correspondence with members of
this branch of the FDA. (I am aware that the cutbacks in FDA funding may
have played a role in this issue.) It became apparent that the essential
medical details (e.g. patient identity, genetic background, family history
of autoimmune diseases, etc.) are not provided by this reporting system
and that there is no way to contact physicians reporting these reactions.
This information is, therefore, inadequate and not accessible to those of us
who are studying the serious adverse reaction events apparently related to
this vaccine. It was also apparent that there is no follow-tip on these
reactions since the two patients I reported were never contacted to evaluate
their deteriorating health conditions.
What was obvious from the information I obtained from the VAERS reports
were that there are thousands of reports listing such conditions as
neurological damage, arthritis symptoms, and otherserious immunological
disorders. These are the same types of medical conditions that, in my
extensively detailed investigation of the literature, have been published in
dozens of medical journals that cite the correlation of this vaccine and
severe immunological reactions. (Table of references to be provided at time
of hearing). The fact that this reporting system is "passive", i.e. not
mandatory, also suggests that only some fraction of adverse events
(estimated by FDA officials as 1-10%). In summary it is my opinion that the
VAERS system, as currently structured, is highly inadequate to collect
scientifically useful information.
I have now been in direct contact with hundreds of severely ill patients
(as well as with physicians who have hundreds more patients) having
developed adverse reactions to this Hepatitis B vaccine. I feel that it is
critical to investigate the early onset effects as well as subsequent
development of autoimmune adverse reactions in the hope that we might find
more directed treatments to avert the long term effects in those already
afflicted with these problems. I believe this is possible in view of new
technologies for treatment of autoimmune diseases that are targeted to the
identification of specific autoantibodies to defined epitopes.
2.Do the benefits of administering the vaccine to infants outweigh the
To date my studies have concentrated on the adult population. Sadly, even
less is known about immunological reactions in infants, especially since
they cannot communicate, as can older children or adults, their severe pain,
fatigue, or other neurological or physical disturbances. In the event of
deaths following vaccination, there is generally inadequate information
collected by pathologists to adequately evaluate these reactions.
I would challenge any colleague, clinician or research scientist to claim
that we have a basic understanding of the human newborn immune system. It
is well established in studies in animal models that the newborn immune system is very distinct from the adolescent or
adult. In fact, the immune system of newborns in animal models can easily
be perturbed to ensure that it cannot respond properly later in life. In
contrast, it is highly improbable in the US that a newborn has any
significant risk of contracting Hepatitis B as a child because the disease
is caused by a blood-borne virus. Newborns are not likely to engage in
intravenous drug use or promiscuous sex. Nor are they likely to suffer an
accidental needle stick, as might a medical worker. About the only way they
are likely to be exposed to the disease is by being born to an already
In view of this lack of scientific and medical information of neonatal
immunology, it is remarkable to me that newborn infants, especially those
not at risk for the Hepatitis B disease itself are being administrated
multiple injections of this vaccine and that there have been few, if any,
clinical trials to adequately evaluate the potential long term effects of
neonatal immunization especially as it relates to genetic diversity. 3.
What process does the CDC employ to make a recommendation for a vaccine:
What role do pharmaceutical companies play in that process? Do conflicts of
As I am not an expert on public health policy, I am not familiar with all
of the nuances of policies for recommending vaccine mandates. It is well
documented, however, that committee members advising the CDC and members of
organizations (such as the American Academy of Pediatrics, and the World
Health Organization) obtain substantial finding from pharmaceutical
companies. Furthermore, it is well documented that investigators who have
carried out clinical trials on this vaccine also benefit personally and
obtain laboratory funding as consultants promoting the vaccine and as expert
witness in legal conflicts. It is also documented that lobbyists who
consult for pharmaceutical companies are the same lobbyists for medical
health care providers. I leave it up to this distinguished committee to
investigate and evaluate the seriousness of these apparent conflicts of
However, it is also apparent to me that the lack of government funding
specified for independent scientists to evaluate adverse vaccine reactions
is a major reason for scientists to seek funding for experiments dictated by
4.What disclosure is required before the vaccine is given? Is it
It is apparent to me, as it is to many others who have been investigating
this issue, that adequate long-term follow-up information was not collected
in clinical trials for this vaccine. This is particularly true with respect
to the Caucasian population. One might therefore ask: "Is there is
sufficient information concerning risks of this vaccine to be disclosed"?
The ominous lists of potential reactions listed in the vaccine inserts
appear not to be given to patients by their physicians. The
physician-patient relationship is fiduciary. That is why the lawyer
representing my brother, who had an adverse reaction to this vaccine, made a
claim of fraud, a claim which this lawyer says has a strong basis in the
Restatement of Torts.
Many physicians and medical students have told me that, if this vaccine
is recommended and mandated by government officials, "why should they look
at it or discuss it with their patients?" Others have said that their
colleagues do not report these incidences because they "don't want to get
involved." They further tell me that they have been informed that this
vaccine is the safest ever developed because it is a recombinant DNA vaccine
and "therefore you can't get the disease". Unfortunately, they have clearly
missed a major point of basic immunology. Any peptide (a limited sequence of
amino acids of a protein) or a full length or
truncated protein (produced by purification from a biological source or
using recombinant CDNA technology) when introduced into the body will be
"processed by the immune system" and, depending on the nature of that
protein, could result in long term autoimmune reactions.
Sadly, in basic science courses in medical schools. many of these details
of immunology (a medical research field that has exploded over the last
decade) are not taught. I have taught in the basic science curriculum for
over 15 years so I am well aware of this limitation. In fact, I recently was
invited to speak at the Institute of Medicine at the National Academy of
Sciences on this subject. I was quite shocked when a senior member of a
national health committee (involved in recommending mandates for childhood
vaccines) came up to me and said: "Very interesting talk. I know you teach
beginning medical students. Could you recommend me a basic immunology
textbook? I think I need to catch up on some of this immunology stuff."
In summary, it is essential in my opinion that physicians be better
educated on the potential risks of this vaccine, as well as the interactions
with other vaccines and the increased risks of vaccinations of sick
children. It is also critical1v important to conduct the research necessary
so that they will have better information to identify people at risk for
adverse reaction. In any event early diagnoses of these reactions will
result in more effective therapies.
My colleagues and I have submitted proposals to investigate the
scientific bases for these vaccine adverse reactions. Many of these
reactions are similar to those reactions from individuals having the virus
itself. It is also apparent that there are major histocompatability, genetic
linkages among patients who are having the severe reactions. It has already
been shown that as many as 10 to 30% have been reported as not developing
antibodies when they are vaccinated and, therefore, they may not to be
protected from the disease. This non-responsiveness may be attributed to the
individual histocompatability genes.
We have proposed to carry out research to determine the long-term
prognosis for patients having such adverse reactions for two purposes: (1)
Developing a prophylactic strategy of identifying those likely to react
adversely so they can avoid the vaccine if at risk; and (2) developing a
therapeutic strategy by early and more effective identification of those who
have had adverse reactions with the hope of developing more specific
therapies. I and my collaborators have well equipped laboratories for state
of the art immunological and biochemical analyses and we have already
collected blood samples throughout the period of these adverse reactions. We
therefore, have unique samples to begin to scientifically pinpoint the
reasons for the adverse reactions. We have significant preliminary evidence
that may explain these responses and we will continue to seek funding to
continue these studies. We have obtained some limited funding from private
sources but as yet there are no government funds allocated for studying
adverse reactions to this vaccine, so the progress of these studies is slow.
It is apparent that the Hepatitis B virus (and vaccine developed from the
Hepatitis B surface antigen) is very unique from many other viruses and
vaccines. New theories and experiments (i.e. molecular mimicry and anti-idiotypic
antibodies) have been developed which could explain reasons for autoimmune
caused by this virus or the viral protein used in the vaccine. (The
December 26, 1996, New York Time's article which summarizes studies on
"molecular mimicry" theories for viruses causing autoimmune diseases may be
right on point.) The fact that there are dozens of publications on the
correlation of this virus as well as the vaccine with autoimmune and other
connective tissue disorders provides strong evidence for the correlation of
this viral antigen causing autoimmune diseases.
In summary, no one, especially myself. would ever assert that the
Hepatitis B virus is not causing serious health problems in the world.
However, if this, or any other vaccine, by nature of the protein or parts of
the protein (native or produced from a cDNA as a recombinant protein), has
the ability to adversely effect the immune system of large numbers of
individuals resulting in severe adverse reactions (even if restricted to
some genetic populations), then the public reaction to ALL vaccines,
including those that clearly DON'T have related adverse reactions will be
doomed in the public's eye. That includes the development of vaccines to
evolving airborne viruses that might become a serious threat to the world
population. Thanks to the success of the Government funded Human Genome
Project and advances in computer programs, it may soon be possible to
evaluate potential molecular structure to predict these problems with
vaccine in advance or early in vaccine development.
I will conclude by relating an observation. In my research on vaccines
that have been used for the humane control of animal populations, I have had
the opportunity to observe first hand African elephant family behavior.
Whenever a baby cries, the entire herd of up to a hundred will immediately
trumpet, and charge with great flurry to surround the infant elephant.
When it is apparent that there is no danger, they will one by one touch
trunks with that infant, ensuring that he is okay before going about their
business. They would certainly never allow a single baby or family member to
be exposed to unknown danger.
I ask you in your task of investigating our public health system that as
do our friends the elephants, listen to the cries of babies (and family
members) that might have been adversely affected by this vaccine or who may
be at risk. Please demand adequate scientific documentation and medical
information to make responsible decisions concerning mandating vaccines
for children. In addition to your investigation on the adverse reactions
of this vaccine I would urge you to help to provide research funds which
are currently not available to study the serious adverse reactions of this
vaccine as well as other vaccines.
Thank you for the opportunity to appear before this
distinguished subcommittee. I will be glad to answer any of your questions
or provide you with additional information you may request.
Bonnie S. Dunbar, PhD, Professor Department of Cell Biology Baylor
College of Medicine, One Baylor Plaza Houston, Texas 77030 Dunbar May
14,1999 Page 6
Acute Hepatitis B Infection after Vaccination
Lancet Vol 345 Jan 1995
Multiple Evanescent White Dot Syndrome After Hepatitis B Vaccine
American J of Ophthalmology Vol 122 No 3 [2pgs]
Systemic Lupus Erythematosus and Vaccination Against Hepatitis B
Nephron 1992; 62 [1pg]
Postmarketing Surveillance for Neurologic Adverse Events Reported After HepB
Vaccination American J of Epidemiology Vol 127 no 2 [16pgs]
Severe Acute Hepatitis B Infection After VaccinationLiver Dysfunction and
DNA Antibodies After Hepatitis B Vaccination Thrombocytopenic Purpura After
Recombinant Hepatitis B Vaccine Lancet Vol 344 [2pgs]
Central Nervous System Demyelination after Immunization with Recombinant Hep
B Vaccine Lancet Vol 338 1991 [2pgs]
Testimony of Betty D. Fluck for U.S. House of Representatives Committee on
Government Reform Subcommittee on Criminal Justice, Drug Policy, & Human
Resources. John L. Mica. Chairman
Effectiveness of Hepatitis B Vaccine
May 18, 1999
I would like to thank you for allowing me to come before you today to share
my experience with you. Never did I dream that I would have this
opportunity. I am a diagnosed victim of the Hepatitis B vaccine. My husband
and I are not anti-vaccine. Each of our three boys has been vaccinated per
Health Department Guidelines. However, they will not have the hepatitis B
vaccine. On December 2, 1997, I took my second Hepatitis B vaccine in the
series of three. I was required to have the immunization for my job. I am a
Registered Nurse and have been for twenty years. I had just started a new
job as a Public Health Nurse for the local Health Department in Kokomo,
Indiana. Part of my job description was to give immunizations in the
department's weekly clinic.
Roughly twelve hours after receiving my vaccine, I woke up in severe pain -
I developed a 104 F fever, nausea and vomiting, respiratory problems, a
rash, severe head, neck and back pain, swollen joints and I was unable to
move my legs. When the fever broke several hours later, I regained a small
percentage of my leg strength. but the severe damage had already been done.
I had to use a cane to move around. I had absolutely no energy and I had
constant joint and leg pain. I was sleeping approximately 22 hours per day.
I continued to rim intermittent low grade fever.
The first doctor that I went to said that I had a reaction to the Hepatitis
B vaccine but was unable to help. I went from doctor to doctor looking for
help. I ended up at Indiana University Medical Center in Indianapolis. I
first saw a doctor who was very kind and told me that he had read about some
of the problems with the vaccine. He promised to do some research into the
vaccine adverse reactions. He asked me to see one of his colleagues at I. U.
Med Center, a rheumatologist. This rheumatologist from I U. was simply
hostile to the idea that the Hepatitis B vaccine could have caused my
problems. He suggested that some of my problems could be attributed to a
kidney stone. Please be aware that at that point, my fingers were so painful
that I could not open a soda can.
I returned to the first doctor at I. U. Med Center one month later for a
scheduled follow up. This doctor who had been encouraging and sympathetic
one month ago now refused to use the word vaccine and attributed some of my
problems to the "aging process". Unhappy with both of these doctors, I
requested a meeting with a patient advocate and the I. U. doctors. At this
meeting, the first doctor finally told me that I had a "political problem.
not a medical one."
My condition continued to deteriorate from cane, to walker, to kneebraces.
Finally in September, 1998, 1 was put in full leg braces that run from my
toes to my hips. With the use of the braces and forearm crutches, I have
some mobility. Eight months after the initial injury, I was able to find an
out of state doctor who was treating people for vaccine damage. I must now
see him every three months.
The vaccine has caused nerve damage to my legs and hands. The medical name
for my problem is Chronic inflammatory Demylenating Polyneuropathy (CIDP). I
also have multiple types of auto immune disorders, and I now have an
elevated rheumatiod arthritis factor. I undergo weekly IV treatment s that
cost several thousand dollars per week. Although I have more energy now
there is no real prognosis for my condition.
Immediately after I was injured, I contacted the pharmaceutical company
asking them for help. They told me that they had never heard of this problem
before. I realized at that point that I was not that unique and
decided to write to the FDA through the Freedom of Information Act. I
requested any reports on file about adverse reactions to the Hepatitis B
vaccine for one particular company from 1991 to present. Four months later I
received a box containing a 1045 page report. On each page, there were
summaries of approximately eight reactions . These 8000 + reactions ranged
from mild to death.
I made an appearance on ABC's 20/20 in January, 1999 on their story about
the Hepatitis B vaccine. Since that show was aired. I have received numerous
calls from adult victims and parents of children who have been injured after
taking the Hepatitis B vaccine. One common theme among victims is that their
doctors told them that it couldn't be the vaccine because it was perfectly
I recently testified for the State Senate Committee in Indiana with the
intent of removing the mandate for the Hepatitis B vaccine for school entry.
The proposed ammendment was designed to give the parents the choice to wave
the vaccine for any reason.
On March 2, 1999, it passed the State Senate by a vote of 45 to 4. However,
the House sponsor of the original bill killed it rather than bring the bill
up for debate.
In Indiana, a doctor from the Department of Health told the Senate Committee
that one of the arguments for the vaccine was that it was the "first
anti-cancer vaccine." Fortunately, we were able to show that the
"anti-cancer vaccine" theme was taken from the PATH website. PATH is an
organization within the World Health Organization. PATH suggested that the
"first anti-cancer vaccine" theme was a good marketing tool to bring about
interest in a "boutique" vaccine.
I have minutes from a CDC Study Group Meeting on the Hepatitis B vaccine
held in March, 1997. The minutes of the meeting show that it would take at
least a 60 day study to show the onset of MS. Clinical studies done by the
two manufacturers were four and five days in length, respectively. It should
be noted that the afternoon session of this meeting was chaired by Dr.
Robert Sharrar of Merck. This group was to decide how to identify various
types of adverse reactions such as MS and demylenating disease and to plan
meaningful studies. When Dr. Sharrar appeared on ABC's 20/20 in January he
said that he honestly believed that the Hepatitis B vaccine had not caused
any problems. Can an employee of a pharmaceutical company that manufactures
the vaccine be objective in designing experiments to show fault in a product
that generates close to a billion dollars in sales for his company?
The form that people are given about the vaccine was written by the CDC. It
does not address serious adverse reactions. When you look at the vaccine
insert provided by the manufacturer, several adverse reactions are noted. I
have since talked to many Healthcare professionals who are also unaware of
the potential adverse reactions listed on the vaccine insert. It makes me
wonder why the pharmaceutical company representative that I talked with
earlier, the one who was unaware of any adverse reactions, was unaware of
what their own company's insert said. A vaccine that still has so many
unanswered questions should not be mandated for children. It just does not
make sense. The right to decide if it is in the best interest of the child
should be made by the parents. After all, it appears that for the most part
when a child is severely handicapped by this vaccine. the parents are on
their own. No one pushing the mandate is there for help or comfort.
In an article on the Hepatitis B vaccine that was printed in the Washington
Post. a spokesperson for the CDC, said that nothing unexpected had been
observed in the way of adverse reactions. At first. I thought they meant
that their position was that no adverse reactions had occurred. Now, I
really don't think it was denial. Despite over 20,000 reports to VAERS for
the two manufacturers nothing unexpected had occurred. I really believe that
the number and type of injuries is no surprise to the CDC. May be the only
surprise for the CDC is just how hard the victims are fighting back.
BETTY D. FLUCK
Clin Rheumatol. 2003 Dec;22(6):461-3. Epub 2003 Oct 07. Related Articles,
Kawasaki disease in an infant following immunisation with hepatitis B
Miron D, Fink D, Hashkes PJ.
HaEmek Medical Center, Afula, Technion Medical School, Haifa, Israel.
The known association between hepatitis B and vasculitis has been reported
in rare cases in adults after hepatitis B vaccination. We here describe a
35-day-old infant who developed Kawasaki disease 1 day after receiving his
second dose of hepatitis B vaccine. Although extremely rare, this possible
side effect should be noted and further investigated.
PMID: 14677029 [PubMed - in process]
Pediatrics 1980 Oct;66(4):633-6
Urine mercury levels in Kawasaki disease.
Orlowski JP, Mercer RD
Six patients with diagnostic criteria for Kawasaki disease had abnormally
high urinary excretions of mercury. They were compared by age, sex, and
geographic location with matched controls. Improvement of one patient was
temporally related to chelation of mercury with penicillamine. There are
numerous clinical similarities between acrodynia and Kawasaki disease and
the appearance of the mucocutaneous lymph node syndrome (Kawasaki disease)
has been related
temporally and geographically to environmental pollution with mercury. The
mucocutaneous lymph node syndrome(Kawasaki disease) may represent a disease
caused by environmental pollution with mercury, or clinical symptoms
compatible with Kawasaki disease may indicate environmental
exposure to mercury.
Clin Exp Rheumatol. 2004 Nov-Dec;22(6):749-55. Related Articles, Links
A case-series of adverse events, positive re-challenge of symptoms, and
events in identical twins following hepatitis B vaccination: analysis of
Vaccine Adverse Event Reporting System (VAERS) database and literature
Geier MR, Geier DA.
The Genetic Centers of America, MedCon, Inc., Silver Spring, Maryland
OBJECTIVES: Adverse events and positive re-challenge of symptoms reported
in the scientific literature and to the Vaccine Adverse Event Reporting
System (VAERS) following hepatitis B vaccination (HBV) were examined.
METHODS: The VAERS and PubMed (1966-2003) were searched for autoimmune
conditions including arthritis, rheumatoid arthritis, myelitis, optic
neuritis, multiple sclerosis (MS), Guillain Barre Syndrome (GBS),
glomerulonephritis, pancytopenia/thrombocytopenia, fatigue, and chronic
fatigue, and Systemic Lupus Erythematous (SLE) following HBV. RESULTS:
HBV was associated with a number of serious conditions and positive
re-challenge or significant exacerbation of symptoms following
immunization. There were 415 arthritis, 166 rheumatoid arthritis, 130
myelitis, 4 SLE, 100 optic neuritis, 101 GBS, 29 glomerulonephritis, 283
pancytopenia/thrombocytopenia, and 183 MS events reported following HBV A
total of 465 positive re-challenge adverse events were observed following
adult HBV that occurred sooner and with more severity than initial
adverse event reports. A case-report of arthritis
occurring in identical twins was also identified.
from biological plausibility, case-reports, case-series, epidemiological,
and now for positive re-challenge and exacerbation of symptoms, and
events in identical twins was presented. One would have to consider that
there is causal relationship between HBV and serious autoimmune disorders
among certain susceptible vaccine recipients in a defined temporal period
following immunization. In immunizing adults, the patient, with the help
of their physician, should make an informed consent decision as to
be immunized or not, weighing the small risks of the adverse effects of
HBV with the risk of exposure to deadly hepatitis B virus.